The Auer Lab

Innovative Cancer Research 

Ananth AA, Tai LH, Alkayyal A, Zhang J, Tanese de Souza C, Stephenson K, Pol J, Parato, K, Stojdl DF, Atkins HL, Bell JC, Lichty BD, Auer RC. Surgical stress attenuates pre-existing anti-tumour immunity resulting in postoperative metastases and local recurrence in a murine model. PLoS One (published online May 19, 2016, doi.org/10.1371/journal.pone.0155947).


Alkayyal AA, Mahmoud AB, Auer RC. Interleukin-12 expressing oncolytic viruses: a promising strategy toward cancer immunotherapy. J Taibah University Med Sci 2016 June;11(3):187-193.


Laura Evgin, Carolina S Ilkow, Marie-Claude Bourgeois-Daigneault, Christiano Tanese de Souza, Lawton Stubbert, Michael S Huh, Victoria A Jennings, Monique Marguerie, Sergio A Acuna, Brian A Keller, Charles Lefebvre, Theresa Falls, Fabrice Le Boeuf, Rebecca A Auer, John D Lambris, J Andrea McCart, David F Stojdl, and John C Bell. Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies.

Mol Ther 2015;23(6):1066-76. IF:6.825

Link to Publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111574/


Carolina S Ilkow, Monique Marguerie, Cory Batenchuk, Justin Mayer, Daniela Ben Neriah, Sophie Cousineau, Theresa Falls, Christiano Tanese de Souza, Almohanad Alkayyal, Jiqing Zhang, Fabrice Le Boeuf, Rozanne Arulanandam, Lawton Stubbert, David F Stojdl, Harold L Atkins, Rebecca C Auer, Jean-Simon Diallo, Brian D Lichty & John C Bell et all. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity

Nature Medicine 21, 530–536 (2015) doi:10.1038/nm.3848

Link to Publication: http://www.nature.com/nm/journal/v21/n5/full/nm.3848.html


Tai LH, Tanese de Souza C, Sahi S, Zhang J, Alkayyal A, Ananth A, Auer RC*.  A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression an Evaluate Novel Perioperative Immunotherapies.  J Visualized Experiments 2014;85.  IF: 1.9.

Watch the Publication: http://www.jove.com/author/Rebecca+A.C._Auer


Zhang J, Tai LH, Ilkow C, Alkayyal AA, Abhirami AA, Sahi STanes de Souza C, Lefevbre C, Falls TJ, Bell JC, Stojdl D, Auer RC.  Preventing metastases by perioperative targerting of natural killer cells dysfunction with Maraba MG1 virotherapy. Mol Ther doi:10.1038/mt.2014.60 IF:6.825 

Link to Publication: http://www.nature.com/mt/journal/vaop/naam/pdf/mt201460a.pdf


Tai LHZhang J, Scott KJ, Tanese de Souza C, Alkayyal AAAbhirami Ananth A, Sahi S, Adair RA, Bakur Mahmoud A, Sad S, Bell JC, Makrigiannis AP, Melcher AA, Auer R. Perioperative influenza vaccination reduces post-operative metastic disease by reversing surgery-induced dysfunction in natural killer cells. Clin Cancer Res 2013;19(5104). 

 PMID: 23881927

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/23881927

 

Tai LH, Tanese de Sousa C, Rintoul J, Ly L, Zhang J, Falls TJ, Belanger S, Bell JC, Makrigiannis A, Auer RC*. Preventing postoperative metastases by enhancing natural killer cell function with novel oncolytic virus therapy. Cancer Res 2012;73(1):97-107. IF:7.338

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Link to Publication: http://cancerres.aacrjournals.org/content/early/2012/10/23/0008-5472.CAN-12-1993

 

Lemay CG, Rintoul JL, Kus A, Paterson JM, Garcia V, Falls TJ, Ferreira L, Brindle BW, Conrad DP, Tang VA, Diallo JS, Arulanandam R, LeBoef F, Stojdl DF, Lichty BD, Atkins HL, Parato KA, Bell JC*, Auer RC. Harnessing oncolytic virus-mediated anti-tumour immunity in an infected cell vaccine. Mol Ther 2012;20(9):1791-9. IF:6.825

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/22760544

 

Seth R, Tai LH, Falls T, Tanese de Sousa C, Bell J, Carrier M, Atkins H, Boushey R, Auer RC*. Surgical stress promotes the development of cancer metastases by a coagulation-dependent mechanism involving Natural-Killer cells in a murine model. Ann Surg (epub doi: 10.1097/SLA.0b013e31826fcbdb, October 26th, 2012). IF:7.338

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/23108132

 

Rintoul JL, Lemay CG, Tai LH, Stanford MM, Falls TJ, de Souza C, Bridle BW, Ohashi PS, Wan Y, Lichty BD, Mercer AA, Auer RC, Atkins HL, Bell JC*. ORFV:A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic. Mol Ther 2012;20(5):1148-57. IF:6.825

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/22273579

 

Auer RC, Bell JC*. Oncolytic viruses: smart therapeutics for smart cancers. Future Oncol 2012 Jan;8(1):1-4. IF:2.455

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Link to Publication: http://www.futuremedicine.com/doi/full/10.2217/fon.11.134

 

Le Boeuf F, Niknejad N, Wang J, Auer R, Weberpals JI, Bell FC, Dimitroulakos J. Sensitivity of cervical carcinoma cells to vesicular stoatitis virus-induced oncolysis: potential role of human papiloma virus infection. Int J Cancer 2012 Aug 1;131(3):E204-15. 

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/22173567

 

Auer RC, Scheer AS, Boushey RP, Asmis T, Wells PS, Jonker D, Carrier M. The use of extended peri-operative low molecular weight heparin to improve disease-free survival following surgical resection of colon cancer: a pilot randomized controlled trial. Blood Coagul Fibrin 2011;22(8):760-2. IF:1.408

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Parato KA, Breitbach CJ, Le Boeuf F, Wang J, Storbeck C, Ilkow C, Diallo JS, Falls T, Burns J, Garcia V, Kanji F, Evgin L, Hu K, Paradis F, Knowles S, Hwang TH, Vanderhyden BC, Auer R, Kirn DH, Bell JC. The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers. Mol Ther 2012;20(4):749-58. IF:6.825

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/22186794

 

Le Boeuf F. L., Diallo J., McCart J. A., Thorne S., Falls T., Stanford M., Kanji F., Auer R., Brown C. W., Lichty B. D., Parato K., Atkins H., Kim D., Bell J. C. Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing. Mol Ther 2010;18(5), 888-895.

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/20234341

 

Auer RC, White RR, Kemeny N, Jarnagin W, Dematteo RP, Fong Y, Blumgart LH, D’Angelica M. Predictors of a true complete response among disappearing lesions following chemotherapy for colorectal liver metastases. Cancer. 2010 Mar 15;116(6):1502-9.

Link to Publication: http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/4058

 

Auer RC, Schulman AR, Tuorto S, Gönen M, Gonsalves J, Schwartz L, Ginsberg M, Fong Y. “Use of Helical CT Is Associated with an Increased Incidence of Postoperative Pulmonary Emboli in Cancer Patients with No Change in the Number of Fatal Pulmonary Emboli”. J Amer Col Surg 2009;208:871-880.

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/19476851

 

Lichty B, Stojdl D, Taylor R. Miller L, Frenkel I, Atkins H, Bell J. Vesicular Stomatitis Virus: A potential therapeutic virus for the treatment of hematological malignancies. Hum Gene Therapy. 2004;15(9):821-831. 

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/15353037

 

Taylor R, Reitsma, B, Sarrazin S, Bell M. Early results using a dynamic method for delayed primary closure of fasciotomy wounds. J Amer Col Surg. 2003;197(5):872-878. 

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Link to Publication: http://www.ncbi.nlm.nih.gov/pubmed/1458543